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What is Casein? Casein (kay’seen) is a quick-drying, water based medium with a milk-based binding agent. Casein has the wash capabilities of watercolor, the smooth opacity of tempera and gouache, and the richer textures of oils and acrylics. Brushes dipped incasein keep their finesse, producing clear, crisp lines. Unlike oils, casein is a clean, water-soluble medium requiring …